To be defeated in a computer game, causing the winner's ego to inflate like a party balloon as if such a victory has any tangible significance outside that of his stinking socks-infested dorm room. These people will frequently create animated GIFs of violent sports events where a player gets clobbered by his opponent, complete with blinking neon "PWN3D!" captions, and post them on their blogs to indicate that they should not be messed with.
Person A: Dude, totally like you sooo suck so much, I PWNZ0RED J00!!!!11!!11
Person B: It's a god damned game of rock/paper/scissors, asshole. Please die.