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1.
Slang term for something of big time, major, gigantic or huge proportions.
Hey baby, you got some major league hooters.
af JohnstonGuy 20. juni 2005
 
2.
feces. crap. poop. bowel movement number 2.
Joe: Ah man i gotta take a major league!
Andy: You gotta league it?
af lizzynicz 28. maj 2009