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1.
used in the opposite situation as win, usually when something disappointing has been mentioned
A: I think I just failed a math test
B: Lose.

A: Fuck, Starcraft II doesnt come out for another year.
B: Double Lose.
af vx14 30. november 2007
 
2.
same as the verb, but treated as a noun.
What a lose, I just dropped my ice cream cone.
af Lex Luther Vandross 22. marts 2004
 
3.
1) Noun: an undesirable action; a snitch; a bothersome individual

2) Adjective: used to describe something unfavorable

3) Verb: to do something that is seen as wrong or obnoxious
My bitch ass brother is such a lose; he tells on me for everything.

School is a huge lose.

Why would you do that? That loses.
af H Town Blizzard 15. november 2007
 
4.
To break up with a girl if she ain't doin anythin with you.
"I'm gonna lose this bitch if she don't give out."
af footballstud580 3. april 2004
 
5.
to leave or go out
I'm lose
af the infamous chocolate 23. oktober 2003