Top Definition
The title is a Southern expression meaning at my wit's end.
When things are going so bad you could lose your faith.

Also a fabulous R.E.M. song.
Between the tight job market and my whiny kids I'm loosing my religion.
af pfeifferpack 8. april 2011
1 more definition
Best fucking black metal song ever. But only Graveworm's version, though.
I listened to Loosing my Religion over a dozen times last night.
af Paracetamol 500mg 30. september 2006

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