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1.
Acronym : Knocked The Fuck Out!

Used mainly in internet chat
He got KTFO!!! ( to be said in best Chris Tucker voice )
af alphafemale 2. september 2002
 
2.
When Pacquiao threw the left hook against Hatton
Did you Pacquiao? see KTFO of Ricky Hatton?
af Timmy68986 29. december 2009
 
3.
Acronym for "KNOCKED THE FUCK OUT" - used to describe someone who was not just knocked out in a contact fighting sport, but knocked unconscious.
Did you see the Lyoto/Evans fight? Evans was KTFO!!!!
af jacko23 21. september 2009
 
4.
Knocked The Fuck Out
That guy got K.T.F.O.'d when he got cracked in the dome with that baseball bat!!!
af Sandy L 18. september 2007
 
5.
1) Being punched (and/or kicked) so hard, you go into a state of temporary (or permanent) unconsciousness.

or

2) When an individual goes into a deep slumber. Waking them becomes extremely difficult.
-Example 1
Herman Cain: I told him that I knew I owed him money, but I wasn't paying him a GODDAMN thing. Fuck him! 9-9-9 till I die

Barack Obama: Then what happened?

Herman Cain: Fuck you think happened? I got KTFO!

-Example 2
Bill Clinton: Yeah I hit dat ass, smoked a J, then passed out. She tried to wake me for round 2, but I was KTFO! You know how a nigga do
af goingHaywire 20. januar 2012
 
6.
What would happen if shaq boxed david schwimmer.
Man, did you see what happened in the shaq vs schwimmer fight?

Nah, who won that joint?

Shaq by ktfo.
af larry merchant 4. februar 2011
 
7.
Stands for: Knocked the fuck out.

A mesh of the two acronyms "WTF" and "KO" minus the W.

Most famously coined by Chris Tucker in the film "Friday" featuring himself as well as Ice Cube the rapper.
Aw snaps homie! You got KTFO by that mofo!
af homeslicefromtehhoodz 3. april 2008