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1.
Can be used in the place of "fa sho," as in to agree with another, or to give props to somebody for some tight shit
You heard I got that job at Nike?
That's wassup
af Cheezie 14. oktober 2004
 
2.
An term of agreement.
Zan: Yo, I got a 95% in my Event Management Class!
Orande: Oh Word? I got a 95% too!
Both: THAT'S WASSUP!
af Zans 11. maj 2006
 
3.
Among the same lines as saying, 'okay', 'for sure', 'yeah' or 'awready'. Mostly used down in Texas.

friend #1: "what's going down tonight?..."
friend #2: "we gonna party like rockstars!!"
friend #1: "yo, thats was sup!!"

Joe: "let's get blazed?!?"
Mike: "uhh, thats was up!!"
af eddy cee 14. marts 2008
 
4.
It means that you agree with something or it also means yes. It also means to ask for head.
Hey Samantha! That's Wassup
af Orlando Castillo 7. januar 2004