That stage in the night at which you've had too much to drink, partied too hard, danced too much, or drank that one spirit that really puts you on a downer. The syndrome can often be amplified if the patient is going through some sort of trauma or difficulty in his or her (sober) life. The sufferer will also attempt to start deep, meaningful conversations with friends or even unknown passers by, spilling out his or her emotions in an attempt to solve his or her problems. This is usually followed by regret the next morning.
some are more prone than others.
Robert: Hey, why's Joe slumped in his chair, not talking to anyone, on his phone (again)?
Laura: ooohh...yeah I forgot to tell you something about Joe...he's got Down Syndrome. Stay well clear of him.
af joeiles 31. august 2008

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A deformity which causes a person (or should I say an ALIEN!!!!!!) to have the face of a bulldog, have a larger forehead, a slope tongue, swollen eyes, a voice which makes them sound like martians (aliens from Mars) and it causes them to be physically and mentally retarded. EEEEEEEEEEEEEEEEEEEWWWWW!!!!
David Allanson: EEEEEEEEEEEEEWWWWWWW!!!! Down syndrome!
af wills0 17. juli 2009

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A term for an addiction to the band System of a Down
Mike listens to System of a Down all day, he has down syndrome.
af m-dubya 28. maj 2005

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What you call someone who has recently been an idiot, asked an extremely stupidass question or is just a flat-out moron.
Person one: hey look at me i'm licking the floor

Person two: ... do you have fucking down syndrome?

Person one: is the Earth flat?

Person two: you have down syndrome.
af Knee-Grow10 17. april 2007

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an insult, to say to ones friends when they are acting 'crippled'
Clutch, are you fuckin down syndrome!
af 106_joN 27. marts 2005

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A phrase used to make fun of someone after they have done something stupid. Also, a disease similar to mental retardation. Many people who have down syndrome have competed in the Special Olympics.
What the hell is your problem! Are you down syndrome or something?
af J-dog 9. april 2005

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very strange...and exessively weird
cara is the coolest kid with down syndrome i know
af ilovematthew 8. maj 2006

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